How hot is it Down Under?

This editorial introduces the 2-part special issue on Temperature-related Sciences in Australia and New Zealand within the journal Temperature ; Part 1: Volume 3, Issue 2 and Part 2: Volume 3, Issue 3. The question posed, “How hot is it Down Under?,” and indeed possible answer(s) can be construed in different ways depending on one’s standpoint. For example, Terra Australis (Latin: “southern land”) is the driest inhabited continent symbolised to many by the scorched Outback and Uluru (Ayer’s Rock) or sun-drenched beaches such as Sydney’s Bondi, while Aotearoa (te reo Maori: “land of the long white cloud”) owes much of its varied and beautiful topography to high volcanic activity and geothermal fields. Alternatively, a search of PubMed using the terms “physiology,” “body temperature” and “Australia/New Zealand” results in 2,251 entries of which >50% are listed within the last 2 decades, illustrating the prolific efforts in temperaturerelated sciences in the antipodes. Despite indigenous people having inhabited Australia and New Zealand for at least 40,000 and 800 years, respectively, Australasia has remained geographically isolated until relatively recently, ensuring much of its biota is unique and native including more than 80% of its florae. In concert with its varied geography and climate, more than 80% of Australia’s mammals are endemic including well-known marsupials such as the kangaroo, koala, and wombat. Weather patterns can restrict a species’ energy intake and activity thereby determining continental distribution, something that Roberts et al. explore by observing foraging and shade-seeking behavior in red and western gray kangaroo species while concurrently measuring local weather. They report that western gray kangaroos spend more time in the shade and foraging than do red kangaroos. Being less able to tolerate radiant heat forces greys to a greater absolute shade requirement. Similarly, the impact of climate and geography on the distribution of Antechinus, a shrew-like marsupial that inhabits a large altitudinal range, is investigated by Cooper et al. who compare the thermal, metabolic, and hygric physiology as a function of ambient temperature in 4 species, 2 from low and 2 from high altitude. They find no differences in the basic physiology of the 4 species, which is similar to other non-alpine species, indicating that marsupials, in general, have adequate physiology for life in alpine environments. Several other papers within this special issue contribute findings from comparative/ecological and conservation physiology such as cold-defense in rats and torpor in desert bats. From unique faunae to rare medical conditions: malignant hyperthermia (MH, incidence of 1: 5,000– 100,000) is a life-threatening disorder that typifies a gene-environment interaction. A triggering agent used during general anesthesia causes a rapid and sustained rise in body temperature that, if left untreated, can be fatal. While MH susceptibility can be diagnosed by testing of skeletal muscle biopsy tissue, it would be advantageous to use DNA testing. However, only 35 of 400C potential variants in the RYR1 gene have been classified and can be used for DNA diagnostic tests. In this issue, Stephens et al. identify that an additional variant should be added to the list of diagnostic mutations for susceptibility to MH. Although hyperthermia can be detrimental to health, it can also be therapeutically beneficial; heat is produced during physical activity, with recent evidence indicating that local and whole-body passive heat generates favorable arterial flow and vascular adaptations. However, only the upper limbs have been assessed, and therefore, Thomas et al. compared lower-limb heating by hot-water immersion with the same duration treadmill exercise in young healthy adults. The hot-water immersion induced positive shear stress and cardiovascular responses in